Wildfire smoke alters immune cells, promoting inflammation

Smoke Beaver Fire
Smoke at the Beaver Fire in Northern California, August 12, 2014. Photo by Bill Gabbert.

Immune cells that normally protect against inflammation and infections can be altered by wildfire smoke to promote inflammation. A long list of diseases are associated with  inflammation. Studies have shown that healthy individuals and those with pre-existing conditions are affected by the very small PM2.5 particles produced by wildfire smoke.

forecast 4 a.m. PDT October 26 fire wildfire smoke
Forecast for the distribution of smoke at 4 a.m. PDT October 26, 2019 in the San Francisco area and south as far as Santa Maria.

Below are excerpts from an article written by Tori Rodriguez first published in Pulmonology Advisor. It covers the effects of smoke on humans and suggests what could be done to mitigate the potential damage. One idea is for fire and local officials when considering evacuation guidelines to plan for not only the dangers of flames, but also the effects of smoke.


[With wildfires increasing] and the health issues that result, there is a real and growing need for clinicians to educate at-risk patients, according to Jennifer Stowell, PhD, a postdoctoral researcher in the department of environmental health at the Boston University School of Public Health and co-author of a recent study on the health effects of wildfires.2 “For clinicians, education of patients is paramount, especially for those with already compromised health,” said Dr Stowell.

Healthy individuals may also experience health consequences from wildfires, according to Angela Haczku, MD, PhD, professor of medicine at the University of California, Davis, School of Medicine and director of the UC Davis Lung Center. “During the 2020 California wildfire season, my team conducted a study on healthy individuals and found alarmingly increased numbers of abnormal, activated immune cells in the peripheral blood.3 These cells are normally responsible for protecting against inflammation and infections, but when altered by inhalation of wildfire smoke, they become the ones promoting inflammation,” she explained.

Research exposes burning issues

The vast majority of recent US wildfires have been concentrated in western states, including Washington (218 fires), California (153 fires), Montana (141 fires), and Utah (130 fires).Estimates show that more than 70,000 wildfires have burned an average of 7 million acres in the US annually since the year 2000.4

In addition to this geographic damage, a sizeable body of research has detailed the negative human health effects resulting from exposure to wildfire smoke:

  • In a study published in June 2022, Heaney et al found that “smoke event” days —  those with the highest amounts of particulate matter 2.5 (PM2.5) from wildfires — were linked to increases in unscheduled hospital visits in California for all respiratory diseases (3.3%; 95% CI, 0.4%-6.3%) as well as asthma specifically (10.3%; 95% CI, 2.3%-19.0%), with the largest effect observed among children ages 0 to 5 years with asthma.2

Stratified analyses demonstrated increased visits for all cardiovascular diseases, ischemic heart disease, and heart failure among non‐Hispanic White patients and individuals older than 65 years. The findings further suggested that the interaction between wildfire PM2.5 concentrations and high temperatures may further increase the need for hospital visits among patients with cardiovascular disease.

  • A 2022 scoping review found evidence of increased population-level mortality, respiratory morbidity, and rates of various types of cancer in association with exposure to PM2.5 and chemicals from wildfire smoke.5
  • Findings from a 2021 study indicate that particulate matter from wildfire smoke has a greater effect on respiratory health than particulate matter from other sources of emission, based on a comparison of the increase in respiratory hospitalizations associated with increases in wildfire-specific PM2.5 (increase in hospitalizations ranging from 1.3% to 10%) and non-wildfire PM2.5 (increase in hospitalizations from 0.67% to 1.3%) in Southern California.6
  • Research published in 2021 showed that a 10 µg/m3 increase in wildfire PM2.5 was correlated with increased hospitalizations for all respiratory diseases, asthma, chronic obstructive pulmonary disease (COPD), and ischemic heart disease in Colorado. Wildfire PM2.5 was also associated with an increase in deaths due to asthma and myocardial infarction.7
  • Other results reported in 2021 linked wildfire PM.2.5 exposure in Alaska to elevated odds of asthma-related emergency department (ED) visits among various population, with odds ratios ranging from 1.10 (95% CI, 1.05-1.15) to 1.16 (95% CI, 1.09-1.23).8
  • A 2018 study analyzed data pertaining to 21,353 inpatient hospitalizations, 25,922 ED presentations, and 297,698 outpatient visits during periods of heightened smoke exposure from the 2007 San Diego wildfires. The results demonstrated a 34% increase in ED visits for respiratory diagnoses and a 112% increase in ED visits for asthma. Even greater increases in ED visits were observed among children aged 0 to 4 years with respiratory diagnoses  (73% increase) and in children aged 0 to 1 year with asthma (243% increase).9
  • Studies have also demonstrated increases in ED visits and hospitalization rates for asthma and other respiratory diseases in relation to wildfire PM2.5 in states such as Oregon and Nevada.10,11
  • Additionally, findings from multiple studies point to a potential connection between wildfire smoke exposure and higher rates of COVID-19 infection and associated mortality. In 1 study, researchers found that COVID-19 cases and related deaths increased by 56.9% and 148.2%, respectively, after the onset of the California wildfires that began in September 2020 compared with the period of time from the onset of the pandemic to just before the wildfires began.12
  • Results of another recent study suggest that “wildfire smoke inhalation sequesters activated, pro-inflammatory [natural killer] cells to the affected tissue compartments and may interfere with [COVID-19] vaccine effectiveness,” according to the authors.13

We interviewed Drs Stowell and Haczku to find out more about what clinicians need to know about the health effects of wildfires. Notably, Dr Haczku recently chaired the 2022 third annual NorCal Symposium on Climate, Health, and Equity.

“The size of the particulate matter is important….Particles larger than 10 micrometers in diameter are deposited in the nose, mouth, and upper airways, while PM2.5 is sucked directly down to the alveoli…causing disruption and inflammation.”
Dr Angela Haczku, Director of the University of California Davis Lung Center and chair of the 2022 NorCal Symposium on Climate, Health, and Equity.

What is known about the health effects of exposure to wildfire smoke?

Dr Stowell: Several studies have investigated the health effects of wildfire smoke and have linked smoke exposure to respiratory disease, cardiovascular disease, and birth outcomes such as preterm birth and low birth weight.14 Several gaps remain, including a better understanding of indoor air quality during wildfire events, the risk to outdoor workers, pregnancy complications, and mental health.

Dr Haczku: Wildfire smoke contains particulate matter of varying sizes, usually classified into PM10 and PM2.5 and ozone (O3) and nitrogen-containing toxic gases. All of these are combined with volatile organic chemicals that fuel the flames, the quality and quantity of which depend on whether what is burning comes from wild land, urban areas, or combined areas.

The size of the particulate matter is important because it determines where in the respiratory tract it will end. Particles larger than 10 micrometers in diameter (PM10) are deposited in the nose, mouth, and upper airways, while PM2.5 is sucked directly down to the alveoli, the tiny sacs responsible for our breathing, causing disruption and inflammation.

These particles are also carriers of inflammatory, allergenic, infectious, and toxic molecules causing both acute and chronic illnesses.

The most affected and best-studied organs susceptible to wildfire smoke are the respiratory tract and the cardiovascular system. Most ED visits are related to exacerbations of asthma and COPD and heart conditions such as coronary disease. Respiratory and cardiovascular mortality and hospitalization rates are well-known to be increased during wildfires. Affected adults and children also often suffer from anxiety and other mental health conditions. These conditions and the long-term health effects of wildfires are less studied and poorly understood.

What are the implications of these effects for health care systems?

Dr Stowell: Increasing wildfire activity due to climate change will continue to exacerbate these issues. Wildfire smoke exposure used to be thought of as an issue for the western US. However, as seen in the past several years, smoke from large fires and complex fires can reach across the continental US, exposing many individuals to harmful pollutants. Even with this wider spread of smoke, exposure will continue to have the greatest effect on the health of communities close in proximity to the fires, where smoke density is the heaviest.

Often the communities most affected are rural and face distance barriers to accessing proper health care. Thus, the health care systems in these already underserved areas could face capacity and response issues as wildfire smoke exposure continues to increase in western US states.

Dr Haczku: The effect of wildfire smoke on respiratory, cardiovascular, mental, and general health could be alleviated through specific interventions. As such, wildfire-related disasters provide health care systems with an opportunity to take a proactive role. Health care professionals should strategically and intentionally prepare for wildfire smoke events. Educational material should be prepared using professional society-approved guidelines and toolkits. These also need to be translated into the languages of and distributed to patients and potentially affected communities as well as the general public.

Having an efficient local system in place for timely warnings to reduce time spent outdoors during wildfire smoke events is crucial. Preventive measures in schools and indoor public places such as improved air filtration systems should be installed.

What are recommendations or considerations for clinicians to keep in mind when caring for patients in areas most affected by wildfires?

Dr Stowell: Education of patients is paramount. Some other steps could include considering temporary staff increases during wildfire seasons, ensuring the clinic staff are well-educated regarding wildfire smoke safety measures, and partnering with communities to provide clean air options for their patients.

Dr Haczku: In addition to intensive management of risk factors and chronic diseases, I believe implementing preventive measures are the most important. For example, professionals need to make sure that timely public warnings of smoke events are in place. Clinicians and health care workers should have a database that can be used to identify and reach out to vulnerable populations including pregnant women, children, the elderly, and farm and construction workers. Education of these communities and individuals can prevent emergency situations. Susceptible patients suffering from chronic illnesses and workers who cannot avoid outdoor activities may require help with fitting personal respirators and devices and specific consultation by health care workers.

What broader measures are needed to buffer the effects of wildfire smoke exposure and protect vulnerable populations, such as those with respiratory and cardiovascular diseases?

Dr Stowell: Much more needs to be done to plan for these large fire events. This planning includes focusing efforts in the areas most often affected by smoke through increasing health care system capacity, forming mobile health response teams, proper community education, better guidelines for evacuation (as most evacuations are intended to avoid the flames and not the smoke). Another need is access to clean air options, such as providing clean air centers and affordable access to air purification technology, including air conditioning and HEPA filtration.

Dr Haczku: As a health care educator, administrator, and climate change researcher, I see an urgent unmet need for the education of health care professionals about the effects of wildfires and, more generally, of climate change on human health. Vulnerable subjects, especially patients suffering from chronic health conditions, should be identified and educated. Improving advocacy toolkits and updating evidence-based professional guidelines for disease management and preventive interventions to reduce risk and protect health is imperative.

Research efforts to study and better understand wildfire smoke-induced pathologies as well as research to investigate the effectiveness of novel interventions should be better supported.

References

  1. Fire, Weather, and Avalanche Center. Current wildfires burning in the U.S. Accessed September 11, 2022.
  2. Heaney A, Stowell JD, Liu JC, Basu R, Marlier M, Kinney P. Impacts of fine particulate matter from wildfire smoke on respiratory and cardiovascular health in CaliforniaGeohealth. 2022;6(6):e2021GH000578. doi:10.1029/2021GH000578
  3. Teuber M, Flayer C, Linderholm A, et al. Wildfire smoke exposure activates circulating innate immune cellsJ Allergy Clin Immunol. 2021;147(2);Suppl_AB237. doi:10.1016/j.jaci.2020.12.012
  4. Congressional Research Service. Wildfire Statistics. Updated September 2, 2022. Accessed September 30, 2022.
  5. Grant E, Runkle JD. Long-term health effects of wildfire exposure: A scoping reviewJ Climate Change Health. 2022;6:100110. doi:10.1016/j.joclim.2021.100110.
  6. Aguilera R, Corringham T, Gershunov A, Benmarhnia T. Wildfire smoke impacts respiratory health more than fine particles from other sources: observational evidence from Southern California. Nat Commun. 2021;12(1):1493. doi:10.1038/s41467-021-21708-0
  7. Magzamen S, Gan RW, Liu J, et al. Differential cardiopulmonary health impacts of local and long-range transport of wildfire smokeGeohealth. 2021;5(3):e2020GH000330. doi:10.1029/2020GH000330
  8. Hahn MB, Kuiper G, O’Dell K, Fischer EV, Magzamen S. Wildfire smoke is associated with an increased risk of cardiorespiratory emergency department visits in AlaskaGeohealth. 2021;5(5):e2020GH000349. doi:10.1029/2020GH000349
  9. Hutchinson JA, Vargo J, Milet M, et al. The San Diego 2007 wildfires and Medi-Cal emergency department presentations, inpatient hospitalizations, and outpatient visits: An observational study of smoke exposure periods and a bidirectional case-crossover analysis. PLoS Med. 2018;15(7):e1002601. doi:10.1371/journal.pmed.1002601
  10. Gan RW, Liu J, Ford B, et al. The association between wildfire smoke exposure and asthma-specific medical care utilization in Oregon during the 2013 wildfire seasonJ Expo Sci Environ Epidemiol. 2020;30(4):618-628. doi:10.1038/s41370-020-0210-x
  11. Kiser D, Metcalf WJ, Elhanan G, et al. Particulate matter and emergency visits for asthma: a time-series study of their association in the presence and absence of wildfire smoke in Reno, Nevada, 2013-2018. Environ Health. 2020;19(1):92. doi:10.1186/s12940-020-00646-2
  12. Meo SA, Abukhalaf AA, Alomar AA, Alessa OM, Sami W, Klonoff DC. Effect of environmental pollutants PM-2.5, carbon monoxide, and ozone on the incidence and mortality of SARS-COV-2 infection in ten wildfire affected counties in CaliforniaSci Total Environ. 2021;757:143948. doi:10.1016/j.scitotenv.2020.143948
  13. Sanghar GK, Ravindran R, Teuber MJ, et al. Phenotypic evaluation of natural killer (NK) cells in response to BNT162b2 mRNA Covid-19 vaccine during wildfire smoke exposure. Presented at: the American Thoracic Society (ATS) 2022 International Conference; May 13-18, 2022; San Francisco, CA. Abstract A5407. doi:10.1164/ajrccm-conference.2022.205.1_MeetingAbstracts.A5047
  14. Evans J, Bansal A, Schoenaker DAJM, Cherbuin N, Peek MJ, Davis DL. Birth outcomes, health, and health care needs of childbearing women following wildfire disasters: An integrative, state-of-the-science reviewEnviron Health Perspect. 2022;130(8):86001. doi:10.1289/EHP10544

Wildfires degrade public health across the country

South Moccasin Fire in Montana, October, 2021
South Moccasin Fire in Montana, October, 2021. Photo by Lauren Kokinda, BLM.

By Matt Vasilogambros 

As wildfires continue to burn in parts of the United States, state public health officials and experts are increasingly concerned about residents’ chronic exposure to toxin-filled smoke.

This year has seen the most wildfires of the past decade, with more than 56,000 fires burning nearly 7 million acres nationwide, according to the National Interagency Fire Center. While the total area burned is less than in some recent years, heavy smoke has still blanketed countless communities throughout the country.

Climate change is causing more frequent and severe wildfires, harming Americans’ health, pointed out Dr. Lisa Patel, deputy executive director at the Medical Society Consortium on Climate and Health, which raises awareness about the health effects of climate change.

“The data we have is very scary,” she said. “We are living through a natural experiment right now — we’ve never had fires this frequently.”

Patel sees the effects of wildfires in her work as a practicing pediatrician at Stanford Medicine Children’s Health, treating more women and underweight and premature infants at the neonatal intensive care unit when wildfires rage in Northern California.

As researchers focus on the public health impact of wildfire smoke, state health and environmental officials across the country have had to issue more air quality notices and provide guidance and shelter for residents struggling during periods of heavy wildfire smoke. And as experts have found, this issue isn’t isolated to the West Coast — it hurts more residents in the Eastern U.S.

Studies show that chronic exposure to wildfire smoke can cause asthma and pneumonia, and increase the risk for lung cancer, stroke, heart failure and sudden death. The very old and very young are most vulnerable. Particulates in wildfire smoke are 10 times as harmful to children’s respiratory health as other air pollutants, according to a study in Pediatrics last year.

What concerns experts is particulate matter in the air smaller than 2.5 microns across; there are around 25,000 microns in an inch. People inhale these microscopic bits, which then can embed deep in their lungs, irritating the lining and inflaming tissue. The particles are small enough to get into a person’s bloodstream, which can lead to other short- and long-term health effects.

Forecast for wildfire smoke
Forecast for wildfire smoke at 12:01 a.m. PDT Sept. 1, 2021.

Particulates in wildfire smoke are even hindering national progress on reducing air pollution, after decades of improvement.

The federal Clean Air Act has substantially decreased the level of toxic particles from industrial and automotive pollution across the country since 1970, the U.S. Environmental Protection Agency notes. But air pollution is expected to worsen in parts of the West because of wildfires, some researchers have found. A United Nations report earlier this year warned of a “global wildfire crisis,” saying the probability of catastrophic wildfires could increase 57% by the end of the century.

Researchers are trying to better understand how more frequent wildfires affect human biology.

Keith Bein, associate professional researcher at the University of California, Davis, created a rapid response mobile research unit in 2017 that he deploys when there are fires around the state. He’s like a storm chaser but for wildfires.

With his mobile unit, Bein can measure particulate matter in the air, take samples back to his lab and then determine their toxicology and chemical compositions. When near these fires, he said, the smoke is so bad that it feels like there’s no escaping it.

“The smoke rolls in, and you get that sinking feeling all over again,” he said.

Massive wildfires that tear through communities are becoming more common. The fires aren’t just burning trees but also synthetic materials in homes. And with repeated exposure to different particulates, health risks are more pronounced and can evolve into chronic conditions, Bein said.

Researchers are just beginning to understand how more frequent wildfires in residential areas impact human health, he added.

“It’s happening more frequently every summer,” he said. “The length of the fires is growing. The public exposure to the smoke is also growing. Once-in-a-lifetime events are happening every summer. This is a different kind of exposure.”

In 2020, a study in Environment International found that winter influenza seasons in Montana were four to five times worse after bad wildfire seasons, which typically last from July until September. The findings shocked study lead author Erin Landguth, an associate professor at the University of Montana.

“We know that hospitalizations for asthma and other respiratory conditions spike within days or weeks of wildfires,” she said. “The thought that this could potentially lead to effects later and how that can affect our immune system is really scary.”

Landguth is currently expanding her study to all Western states. She expects to find a similar trend throughout the Mountain West and Pacific Northwest. Monsoon season in Arizona and New Mexico may disrupt the trend there, she said, while air pollution is already so bad in California from smog and other pollutants that it might be difficult to pinpoint how wildfires are harming human health.

But wildfires are not just in the West, nor is their health impact geographically isolated. Some fires burn so intensely at such high temperatures that smoke rises into the atmosphere, where strong winds can carry the smoke long distances.

This was glaringly apparent in 2021 when the sun glowed red, and the sky hazed over New York City and throughout the Northeast, as smoke drifted from massive wildfires in California, Oregon and other Western states.

Pine Gulch Fire
Shot from Colorado National Monument August 7, 2020 about 15 miles Southwest of the Pine Gulch Fire. The view is looking towards the northeast and shows some of the explosive activity on the northern front Friday and the huge smoke plume extending to the east. Photo by Jennifer Deering.

That smoke is hurting the health of more people in the Eastern U.S. than it is in the West, said Katelyn O’Dell, a postdoctoral research scientist at George Washington University, who released that finding in a study in GeoHealth in 2021. Wildfire smoke contributed to more asthma-related deaths and hospital visits in Eastern communities than those in the West, she and other researchers found, in part because of higher population density.

The smoke hitting the Eastern U.S. doesn’t just come from the West; there are wildfires and prescribed burns throughout the country, said O’Dell.

“It’s sometimes easy to feel distant from fires and their impacts when you’re far from the flames of these large Western wildfires that are in the news,” she said. “But wildfires impact the health of the U.S.”

The next orange sunset people enjoy should be a moment to check an air quality mobile app, she said.

In Minnesota, the state has issued 46 air quality alerts since 2015, according to the state’s Pollution Control Agency. Of those, 34 were due to wildfire smoke, and 26 of those were issued last year.

That took state officials by surprise, said Kathy Norlien, a research scientist at the Minnesota Department of Health. The wildfire smoke risk is not just coming from the plumes that drift from the West Coast and Canada, but also from wildfires in the Boundary Waters — a lake-filled region in the northern stretches of the state. She expects the problem to worsen in the coming years.

“At this point, we’re planning for the worst-case scenario,” she said. “We have not had the extent that the Western states have had. But with climate change and concern over drought and the dry conditions, planning is of the utmost importance.”

She meets regularly with the Minnesota Pollution Control Agency and other state officials about how to get the message to state residents about the increasing wildfire risk to public health, encouraging residents to sign up for air quality alerts. State officials also have established larger community centers and buildings as safe air shelters.

The public plays an enormous role in both preventing (nearly 90% of wildfires are caused by humans, according to U.S. governmental data) and adapting to wildfires, many experts say.

For people living in fire-prone areas, there are nonflammable building materials for new homes and indoor air purifiers and upgraded HVAC systems. But these solutions may be too costly for some families, said Patel, of Stanford Medicine.

She counsels families about how to affordably stay safe during wildfire season, encouraging the use of N95 and KN95 masks, which were pivotal in combating the spread of the coronavirus. She also shares designs for do-it-yourself air filtration systems.

But she emphasized that wildfires will continue to rage across the country and cause adverse health effects unless climate change is reined in through serious public policy. Until then, climate change will continue to be the biggest threat to public health, she said.

“Summer used to be a time I’d look forward to,” she said, “but now I look at it with dread with the heat and wildfires.”


First published by Pew Charitable Trusts on Stateline. Used with permission.

Firefighting classified as carcinogenic to humans

We asked scientists how the findings apply to wildland firefighters

crew from Minnesota
A crew from Minnesota mopping up on the King Fire east of Placerville, California in 2014. Incident Management Team photo.

The International Agency for Research on Cancer (IARC), the cancer agency of the World Health Organization (WHO), has evaluated the carcinogenicity of occupational exposure as a firefighter.

A Working Group of 25 international experts, including 3 Invited Specialists from 8 countries was convened by the IARC Monographs program for a meeting in Lyon, France.

After thoroughly reviewing the available scientific literature, sufficient evidence led the Working Group to classify occupational exposure as a firefighter as carcinogenic to humans.

A summary of the final evaluations has now been published. The detailed assessment will be published in The Lancet Oncology in 2023 as Volume 132 of the IARC Monographs.

Evidence for cancer in humans 
The study found that occupational exposure as a firefighter causes cancer. There was sufficient evidence for cancer in humans for mesothelioma and bladder cancer.

There was limited evidence for cancer in humans for the following cancer types: colon cancer, prostate cancer, testicular cancer, melanoma of the skin, and non-Hodgkin lymphoma.

Strong mechanistic evidence 
The evaluation of the mechanistic evidence was based on exposures associated with fighting structure and wildland fires. There was strong mechanistic evidence in exposed humans that occupational exposure as a firefighter exhibits 5 of the 10 key characteristics of carcinogens: “is genotoxic”, “induces epigenetic alterations”, “induces oxidative stress”, “induces chronic inflammation”, and “modulates receptor-mediated effects”.

Exposure of firefighters
Firefighters are exposed to a complex mixture of combustion products from fires (e.g. polycyclic aromatic hydrocarbons, volatile organic compounds, metals, and particulates), diesel exhaust, building materials (e.g. asbestos), and other hazards (e.g. heat stress, shift work, and ultraviolet and other radiation). In addition, the use of flame retardants in textiles and of persistent organic pollutants (e.g. per- and polyfluorinated substances) in firefighting foams has increased over time.

This mixture may include many agents already classified by the IARC Monographs program in Group 1 (carcinogenic to humans), Group 2A (probably carcinogenic to humans), and Group 2B (possibly carcinogenic to humans). Dermal exposure, inhalation, and ingestion are common routes of exposure, and biomarker studies among firefighters have found enhanced levels of markers of exposure to polycyclic aromatic hydrocarbons, flame retardants, and persistent organic pollutants.


Most studies of firefighter health evaluate structural firefighters. We asked Dr. Kenny Fent and Dr. Kathleen Navarro of the National Institute for Occupational Safety and Health (NIOSH) questions about how these findings apply to wildland firefighters. Here is their joint response:


Summary of IARC Evaluation for Wildland Firefighters
The IARC evaluation of Occupational Exposure as a Firefighter included a review of the available scientific literature on occupational exposures, cancer epidemiology and the key characteristics of carcinogens. The evaluation did not differentiate between structural and wildland firefighters in making the determination of carcinogenicity. This is because the working group was not able to differentiate structure fire exposures (and other exposures) from wildfire exposures for firefighters in at least some of the cancer cohort studies that were included the evaluation.

In addition, many of the studies that provided the evidence of carcinogenicity included the evaluation of the key characteristics of carcinogens (intermediate health outcomes on the pathway to cancer). These included studies of wildland firefighters working on wildfires and prescribed fires.

Lastly, the exposure studies reviewed supported that both structural and wildland firefighters were exposed to similar types of carcinogens. As a result, the definition of “occupational exposure as a firefighter” for the IARC evaluation was kept broad and included a variety of hazards resulting from fires (e.g., structure, wildland, and vehicle fires) and other events (e.g., vehicle accidents, medical incidents, hazardous material releases, and building collapses).

Is mesothelioma only caused by exposure to asbestos, and are wildland firefighters generally exposed to it?
Yes, mesothelioma is caused by exposure to asbestos. Asbestos exposure is generally rare among wildland firefighters, with the exception for wildland firefighters who commonly encounter built environments (especially buildings constructed before the 1970s), areas with contamination (e.g., Libby, MT) or naturally occurring asbestos. A past NIOSH Health Hazard Evaluation reported that exposure to total asbestos fibers in air were less than the lowest occupational exposure limits while conducting a prescribed burn. However, the highest concentrations measured were during tasks with greater plant and soil disturbance and where water was not used (e.g., fire line construction and dry mop-up).


Dr. Kenny Fent leads the National Firefighter Registry at NIOSH and was the chair of the exposure characterization subgroup for the IARC working group.

Dr. Kathleen Navarro leads the Wildland Firefighter Safety and Health program at NIOSH and was a Representative of a national health agency for the IARC evaluation.

Respirator being developed for wildland firefighters

Wildland fire respirator
Development of a wildland fire respirator. Two versions are being tested, with the filter being carried on the chest hip. Department of Homeland Security photo.

A working group for the International Agency for Research on Cancer, the cancer agency of the World Health Organization, has just “classified occupational exposure as a firefighter as carcinogenic to humans.” Part of the reason is the toxic gasses firefighters are exposed to.

Wildland firefighters working on a vegetation fire can’t wear the conventional self contained breathing apparatus used by structural firefighters. It is too bulky, heavy, and only lasts 10 to 30 minutes.

In an effort to provide less carcinogenic air to wildland firefighters, the Department of Homeland Security’s Science and Technology Directorate  is developing a respirator capable of removing airborne hazards present in the wildland firefighting operating environment. They are working with the International Association of Firefighters, National Fire Protection Association, International Association of Fire Chiefs, U.S. Forest Service, and local Colorado fire departments to develop and test the Directorate’s Wildland Firefighter Respirator (WFR). It contains a HEPA filter module that will remove very fine particulates, and a carbon sorbent to remove toxic gases. The team is investigating wildland firefighter-approved designs like the Radio Carrier and Hip-Mounted units shown in the photo below.

Wildland fire respirator
Development of a wildland fire respirator. Two versions are being tested, with the filter being carried on the chest hip. Department of Homeland Security photo.

The WFR was designed around a lightweight mask covering just the mouth and nose. It relies on filtration, designed to go a whole shift before needing to be changed.

“Our system pushes clean air to firefighters using a powered blower with HEPA and carbon filters,” said S&T Program Manager Kimberli Jones-Holt. The system connects to the half-mask through a lightweight, flexible breathing hose to provide clean air and draws in air from the bottom of the unit to prevent rain or water infiltration.

“The filters were also designed to be inexpensive and easily replaced at $5 to $10 each,” Jones-Holt continued.

It uses an electric blower to force filtered air to the mask, relying on AA batteries for power.

The DHS says if wildland firefighters use respiratory protection, their careers could be significantly extended, leading to a more educated and experienced workforce capable of more efficient operations, with lower medical bills and training costs.

Thanks and a tip of the hat go out to Bob.

National Firefighter Registry hopes to begin testing in coming months

Congress required the creation of the registry almost 4 years ago

Lone firefighter in smoke
Image from the NWCG “Wildland Firefighter Mental health” video.

The National Firefighter Registry (NFR) that is supposed to collect data on a voluntary basis to better understand the link between workplace exposures, cancer, and other chronic diseases among firefighters, hopes to begin testing the enrollment system “in the coming months,” according to an update from the leader of the Registry, Kenny Fent.

That is the gist of the message sent by Mr. Fent today, with no other significant details about the registry itself. But he announced three additions to the NFR Subcommittee, one of which is Tom Harbour, the former Director of Fire and Aviation for the US Forest Service. Three members of the Subcommittee are stepping down, including Chuck Bushey who also has a wildland fire background. Mr. Fent said the purpose of the Subcommittee is to “provide independent advice and guidance.”

Almost four years ago the Firefighter Cancer Registry Act of 2018 which passed July 7, 2018 required that the National Institute for Occupational Safety and Health (NIOSH), an agency within the Centers for Disease Control and Prevention (CDC), establish a Firefighter Cancer Registry. Firefighters on the ground have yet to see any concrete examples of the effort, other than changing the name to just “National Firefighter Registry.”

Last year Congress made another attempt to get the registry started by adding a provision into the Tim Hart Wildland Firefighter Classification and Pay Parity Act, legislation which would also accomplish several things to improve the pay and working conditions of federal wildland firefighters. (We covered that legislation in another article.) But the Tim Hart Act has not made it out of committee since it was introduced in the House October 19.

Our take

The National Firefighter Registry has the potential to develop data that documents the health effects of fighting fire. Personnel considering it as a profession could make a better-informed decision in their career choice. And those tactical athletes who have been breathing smoke while working in one of the most physically demanding professions, could have facts to back up claims for treatment of conditions likely caused by the job. Congress and the Office of Worker’s Compensation Programs (OWCP) could better establish presumptive disease policies so that firefighters would not have to attempt to prove that certain cancers or their damaged lungs, knees, or back, were a result of their employment with the government.

Congress must exercise their oversight responsibility and hold hearings if necessary to strongly encourage Kenny Fent, the leader of the FR, to make every effort possible to establish the registry sooner rather than later.

It’s been almost four years.

Firefighters are biased toward action. They know how to get stuff done. Let’s get the NFR done.

Growing body of research points to reproductive health problems for female firefighters

One study showed 27 percent of pregnancies among female firefighters ended in miscarriage

USFS engine crew Descanso, CA 1990
The US Forest Service engine crew at Descanso, California in 1990.

(This article was first published by Grist.org)

By Zoya Teirstein

When Sophia Huston started working as a hotshot — a specialized wildland firefighter with advanced technical training — she was 19 and didn’t know what she was getting herself into. She was physically fit and worked out regularly, but she wasn’t ready for preseason training, when the U.S. Forest Service, the agency she worked for, weeds out the unprepared with intense and physically demanding drills. “You’re going on hikes with full gear and chainsaws,” she said. “I weigh about 115 pounds and I’m carrying about upwards of 80 pounds of gear up a hill. I’m feeling the stress on my body and joints. I’m waking up in the middle of the night to eat food because I can’t get enough calories in.”

Shortly after the training began, Huston got what would be her last menstrual cycle of the fire season. She’s been working in fire for six years now and hasn’t gotten her period for the past three years, which she speculates is due to lack of sleep, poor quality of food, and the physical strain of the job. She doesn’t know what the long-term repercussions of working in the fire service are on her health and fertility. “I just know it’s not good for you,” she said. “It’s not very conducive to fertility and reproductive health.” New research suggests that Huston’s hunch is spot-on.

Smoke, heat, fire-suppressing chemicals, and the physical exertion required to put out and control fires all have effects on humans, but the body of published research on how firefighting affects health is astonishingly small. Studies have shown that being exposed to smoke in general is linked to lung cancer and cardiovascular disease. But little is known about the cumulative impacts of fighting fires year after year, whether soot and other compounds can get absorbed through the skin and cause health problems, and how, exactly, smoke impacts the body in the long-term.

The ways in which fighting fire, and fire itself, affect women are even less understood. Women make up a tiny fraction of the national fire service, both in structural fire departments — the local departments that put out house fires — and the wildland crews that fight fires that occur in the wilderness and areas where wildland meets urban zones. They operate in a system that was built for and around men. And despite evidence that even short-term smoke exposure can affect pregnancy outcomes, female firefighters receive little to no information from their employers on how fire could impact fertility or pregnancy. “Nobody says, ‘smoke is bad, don’t stand there,’” Megan Saylors, a career wildland firefighter for a federal agency, told Grist. “It’s just such an accepted part of our work environment.”

A recent study published in the journal Environmental Health builds on the slim body of research on how work in the fire service specifically affects the reproductive health of women, and trans and nonbinary people who can get pregnant. By analyzing nearly 2,000 pregnancies in more than 1,000 female firefighters, the study found that self-reported miscarriage was 2.3 times more common among female firefighters than it was among female nurses, a cohort that is exposed to similar chemicals and work strains. Twenty-two percent of female firefighters miscarried, compared to 10 percent of female nurses.

The results are similar to those of a 2018 analysis showing that 27 percent of pregnancies in a cohort of 1,821 female firefighters ended in miscarriage — higher than the miscarriage rate in the general population, which is 13.5 percent. But the new study went further by separating firefighters by volunteer versus career status and comparing structural firefighters to wildland firefighters.

The study found that, overall, volunteer firefighters had increased risk of miscarriage compared to career firefighters. And volunteer wildland firefighters had nearly three times the risk of miscarriage compared to career wildland firefighters. Less than 5 percent of career firefighters are women, and 84 percent of the female firefighters in the U.S. are volunteers, which means a disproportionate percentage of the women who fight fires in the U.S. may be at increased risk of miscarriage.

Alesia Jung, a postdoctoral student at the University of Arizona and the lead author of the study, told Grist that she was surprised by the results of her research. She had initially hypothesized that career firefighters would present with the highest risk of miscarriage, because those women are exposed to fires more often than volunteers. “Generally the assumption is that career firefighters who generally respond to more fires in a year would have greater occupational exposures than volunteer firefighters who typically serve smaller communities and may have a smaller amount of fire responses,” she said. “So it was really interesting to see that volunteer firefighters appeared to have a greater risk of miscarriage, and this did vary by wildland firefighter status.”

Jung said that more research needs to be done on why firefighters face such high rates of miscarriage and what can be done to better protect them. Current and former firefighters agree.

Saylors, who has worked on crews based in Alaska, southern Nevada, southern Utah, California, and Oregon, says she’s never worked for a department that had policies or advisories in place to inform women about the risks of the job to their pregnancies. “I know women who were still working on a fire engine doing wildland stuff eight months pregnant. But then you have other people who, as soon as they find out they’re pregnant, they stop doing operational stuff,” she said. “Structural departments and wildland agencies struggle with, what do we do with those women? When do we no longer go put out the fire? When do we no longer go help with a prescribed fire during pregnancy?” Saylors said federal firefighting agencies should collect and conduct research on fertility and put policies in place to protect employees based on that research.

Zora Thomas, a seasonal wildand firefighter working for the Forest Service, told Grist she wasn’t surprised that wildland firefighters face an increased risk of miscarriage due to the requirements of the job. “Exposure to smoke is so ubiquitous and unavoidable, and wearing a respirator really isn’t practical or even possible due to the intensity and duration of our working days,” she said. “It doesn’t surprise me that the obvious occupational hazards we face would have some impact on health and pregnancy, and I would expect that there are also impacts to male reproductive health.”

There’s some evidence that the fertility of male firefighters is also jeopardized by smoke and other hazards of the job. A 2019 study of Danish male firefighters found full-time firefighters were at greater risk of infertility than a comparison group of men in the military. Another study published in October that tracked male fertility in the general population following 10 days of unprecedented hazardous smoke in Oregon during the 2020 fire season found that semen quality greatly deteriorated following the onset of hazardous air quality. “Among male firefighters, reproductive issues are also a topic of concern,” Jung said. She hopes that future studies will help isolate the factors behind firefighters’ fertility problems and shift the status quo so women, and men, are better protected on the job.

Huston isn’t waiting around for the Forest Service to figure out how to better protect women. In December, she finished her sixth season as a hotshot in California. It’ll be her last. “I’m sad to leave but at the same time, I realized this year that I really care about my health, it’s one of my core values and almost everything we do seems to compromise my health,” she said. “Firefighting is a part of my life that I’m very thankful for, but I’m ready to get out.”